The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

A proper self‐regenerating capability is lacking in human cardiac tissue which along with the
alarming rate of deaths associated with cardiovascular disorders makes tissue engineering …

This review presents an extensively integrated model of the cardiac intercalated disc (ID), a
highly orchestrated structure that connects adjacent cardiomyocytes. Classically, three main …

Background Perfluoroalkyl substances (PFAS) are widespread synthetic substances with
various adverse health effects. A potential mechanism of toxicity for PFAS is via epigenetic …

Efficient muscle contraction in skeletal muscle is predicated on the regulation of actin
filament lengths. In one long-standing model that was prominent for decades, the giant …

Supplementation of one-carbon (1C) metabolism micronutrients, which include B-vitamins
and methionine, is essential for the healthy growth and development of Atlantic salmon …

Approximately one-third of known deafness genes encode proteins located in the hair
bundle, the sensory hair cell's mechanoreceptive organelle. In previous studies, we used …

Rationale: With a prevalence of 1 in 200 individuals, hypertrophic cardiomyopathy (HCM) is
thought to be the most common genetic cardiac disease, with potential outcomes that …

Intercalated discs (ICD), specific cell-to-cell contacts that connect adjacent cardiomyocytes,
ensure mechanical and electrochemical coupling during contraction of the heart. Mutations …