Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

The interaction between histones and DNA is important for eukaryotic gene expression. A
loose interaction caused, for example, by the neutralization of a positive charge on the …

Histone acetylation and deacetylation are important epigenetic mechanisms that regulate
gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of …

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA
accessibility. Since then, this process has emerged as a controller of histone and nonhistone …

Histone deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that
play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis …

The mammalian heart is a dynamic organ that can grow and change to accommodate
alterations in its workload. During development and in response to physiological stimuli or …

The zinc-dependent mammalian histone deacetylase (HDAC) family comprises 11 enzymes,
which have specific and critical functions in development and tissue homeostasis. Mounting …

Histone deacetylases (HDACs) modify core histones and participate in large regulatory
complexes that both suppress and enhance transcription. Recent studies indicate that some …

The efficient clearance of cytotoxic misfolded protein aggregates is critical for cell survival.
Misfolded protein aggregates are transported and removed from the cytoplasm by dynein …

Histone deacetylases (HDACs) are considered to be among the most promising targets in
drug development for cancer therapy, and first-generation histone deacetylase inhibitors …