Fluconazole resistance in Candida species: a current perspective
Candida albicans and the emerging non-albicans Candida spp. have significant clinical
relevance among many patient populations. Current treatment guidelines include …
relevance among many patient populations. Current treatment guidelines include …
Triazole antifungal agents in invasive fungal infections: a comparative review
C Lass-Flörl - Drugs, 2011 - Springer
Invasive fungal disease continues to be a problem associated with significant morbidity and
high mortality in immunocompromised and, to a lesser extent, immunocompetent …
high mortality in immunocompromised and, to a lesser extent, immunocompetent …
Contribution of Clinically Derived Mutations in ERG11 to Azole Resistance in Candida albicans
In Candida albicans, the ERG11 gene encodes lanosterol demethylase, the target of the
azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the …
azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the …
Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans
ABSTRACT In Candida albicans, Upc2 is a zinc-cluster transcription factor that targets
genes, including those of the ergosterol biosynthesis pathway. To date, three documented …
genes, including those of the ergosterol biosynthesis pathway. To date, three documented …
Structural insights into binding of the antifungal drug fluconazole to Saccharomyces cerevisiae lanosterol 14α-demethylase
Infections by fungal pathogens such as Candida albicans and Aspergillus fumigatus and
their resistance to triazole drugs are major concerns. Fungal lanosterol 14α-demethylase …
their resistance to triazole drugs are major concerns. Fungal lanosterol 14α-demethylase …
Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens
R Becher, SGR Wirsel - Applied microbiology and biotechnology, 2012 - Springer
Azoles have been applied widely to combat pathogenic fungi in medicine and agriculture
and, consequently, loss of efficacy has occurred in populations of some species. Often, but …
and, consequently, loss of efficacy has occurred in populations of some species. Often, but …
Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?
SL Kelly, DE Kelly - … Transactions of the Royal Society B …, 2013 - royalsocietypublishing.org
The first eukaryote genome revealed three yeast cytochromes P450 (CYPs), hence the
subsequent realization that some microbial fungal genomes encode these proteins in 1 per …
subsequent realization that some microbial fungal genomes encode these proteins in 1 per …
Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design
The cytochrome P450 enzyme lanosterol 14α-demethylase (LDM) is the target of the azole
antifungals used widely in medicine and agriculture as prophylaxis or treatments of …
antifungals used widely in medicine and agriculture as prophylaxis or treatments of …
Candida albicans targets that potentially synergize with fluconazole
Fluconazole has characteristics that make it widely used in the clinical treatment of C.
albicans infections. However, fluconazole has only a fungistatic activity in C. albicans …
albicans infections. However, fluconazole has only a fungistatic activity in C. albicans …
Resistance to antifungals that target CYP51
Fungal diseases are an increasing global burden. Fungi are now recognised to kill more
people annually than malaria, whilst in agriculture, fungi threaten crop yields and food …
people annually than malaria, whilst in agriculture, fungi threaten crop yields and food …