The potential health effects of dietary phytoestrogens
Phytoestrogens are plant‐derived dietary compounds with structural similarity to 17‐β‐
oestradiol (E2), the primary female sex hormone. This structural similarity to E2 enables …
oestradiol (E2), the primary female sex hormone. This structural similarity to E2 enables …
[HTML][HTML] Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause
SD Sullivan, PM Sarrel, LM Nelson - Fertility and sterility, 2016 - Elsevier
Primary ovarian insufficiency (POI) is a rare but important cause of ovarian hormone
deficiency and infertility in women. In addition to causing infertility, POI is associated with …
deficiency and infertility in women. In addition to causing infertility, POI is associated with …
Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition
All women undergo the menopause transition (MT), a neuro-endocrinological process that
impacts aging trajectories of multiple organ systems including brain. The MT occurs over …
impacts aging trajectories of multiple organ systems including brain. The MT occurs over …
Clinical epidemiology of Alzheimer's disease: assessing sex and gender differences
With the aging of the population, the burden of Alzheimer's disease (AD) is rapidly
expanding. More than 5 million people in the US alone are affected with AD and this number …
expanding. More than 5 million people in the US alone are affected with AD and this number …
Estrogen receptors and the aging brain
S Maioli, K Leander, P Nilsson… - Essays in Biochemistry, 2021 - portlandpress.com
The female sex hormone estrogen has been ascribed potent neuroprotective properties. It
signals by binding and activating estrogen receptors that, depending on receptor subtype …
signals by binding and activating estrogen receptors that, depending on receptor subtype …
Endogenous and exogenous estrogen exposures: how women's reproductive health can drive brain aging and inform Alzheimer's prevention
S Jett, N Malviya, E Schelbaum, G Jang… - Frontiers in Aging …, 2022 - frontiersin.org
After advanced age, female sex is the major risk factor for late-onset Alzheimer's disease
(AD), the most common cause of dementia affecting over 24 million people worldwide. The …
(AD), the most common cause of dementia affecting over 24 million people worldwide. The …
Long-term health consequences of premature or early menopause and considerations for management
SS Faubion, CL Kuhle, LT Shuster, WA Rocca - Climacteric, 2015 - Taylor & Francis
Aim To review the current evidence concerning the long-term harmful effects of premature or
early menopause, and to discuss some of the clinical implications. Material and methods …
early menopause, and to discuss some of the clinical implications. Material and methods …
[HTML][HTML] Sex and gender differences in cognitive and brain reserve: Implications for Alzheimer's disease in women
Women represent ⅔ of the cases of Alzheimer's disease (AD). Current research has focused
on differential risks to explain higher rates of AD in women. However, factors that reduce risk …
on differential risks to explain higher rates of AD in women. However, factors that reduce risk …
[HTML][HTML] Role of estrogen and other sex hormones in brain aging. Neuroprotection and DNA repair
Aging is an inevitable biological process characterized by a progressive decline in
physiological function and increased susceptibility to disease. The detrimental effects of …
physiological function and increased susceptibility to disease. The detrimental effects of …
The ageing cortical synapse: hallmarks and implications for cognitive decline
Normal ageing is associated with impairments in cognitive function, including memory.
These impairments are linked, not to a loss of neurons in the forebrain, but to specific and …
These impairments are linked, not to a loss of neurons in the forebrain, but to specific and …