Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

The development of targeted therapies has revolutionized cancer treatment, offering
improved efficacy with reduced side effects compared with traditional chemotherapy. This …

Despite standard hormonal therapy that targets the androgen receptor (AR) attenuates
prostate cancer (PCa) effectively in the initial stage, the tumor ultimately converts to …

Cancer is highly infiltrated by myeloid-derived suppressor cells (MDSCs). Currently
available immunotherapies do not completely eradicate MDSCs. Through a genome-wide …

Abstract Knowledge of the human microbiome, which is likely a critical factor in the initiation,
progression, and prognosis of multiple forms of cancer, is rapidly expanding. In this review …

Urologic cancers (UC) account for 13.1% of all new cancer cases and 7.9% of all cancer-
related deaths. A growing body of evidence has indicated a potential causal link between …

Background The complex etiology and pathogenesis underlying Chronic Non-Bacterial
Prostatitis (CNP), coupled with the existence of a Blood Prostate Barrier (BPB), contribute to …

Background B7-H3 is a cell surface immunomodulatory glycoprotein overexpressed in
prostate cancers (PCs). Understanding its longitudinal expression at emergence of …

The landscape of cancer treatment has been transformed over the past decade by the
success of immune-targeting therapies. However, despite sipuleucel-T being the first-ever …