Glutamate and GABA homeostasis and neurometabolism in major depressive disorder

A Sarawagi, ND Soni, AB Patel - Frontiers in psychiatry, 2021 - frontiersin.org
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

Diabetes and cognitive dysfunction

RJ McCrimmon, CM Ryan, BM Frier - The Lancet, 2012 - thelancet.com
Cognitive dysfunction in type 1 and type 2 diabetes share many similarities, but important
differences do exist. A primary distinguishing feature of type 2 diabetes is that people with …

Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies

FS Luppino, LM de Wit, PF Bouvy… - Archives of general …, 2010 - jamanetwork.com
Context Association between obesity and depression has repeatedly been established. For
treatment and prevention purposes, it is important to acquire more insight into their …

Impact of metabolic syndrome on cognition and brain: a selected review of the literature

KF Yates, V Sweat, PL Yau… - … , and vascular biology, 2012 - ahajournals.org
Metabolic syndrome (MetS), a clustering of risk factors for type 2 diabetes mellitus and
cardiovascular disease, has been associated with cognitive dysfunction and brain …

Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression

E Haroon, CC Fleischer, JC Felger, X Chen… - Molecular …, 2016 - nature.com
Inflammation and altered glutamate metabolism are two pathways implicated in the
pathophysiology of depression. Interestingly, these pathways may be linked given that …

The association between physical activity, fitness and body mass index on mental well-being and quality of life in adolescents

WTB Eddolls, MA McNarry, L Lester, CON Winn… - Quality of Life …, 2018 - Springer
Purpose The purpose of the current study was to investigate the mediatory role between
vigorous physical activity, body mass index (BMI), and cardiorespiratory fitness on symptoms …

Emerging role of glutamate in the pathophysiology of major depressive disorder

K Hashimoto - Brain research reviews, 2009 - Elsevier
Major depressive disorder (MDD) is a common, chronic, recurrent mental illness that affects
millions of individuals worldwide. To date, the monoaminergic systems (serotonin …

MR spectroscopic studies of the brain in psychiatric disorders

RJ Maddock, MH Buonocore - Brain imaging in behavioral neuroscience, 2012 - Springer
The measurement of brain metabolites with magnetic resonance spectroscopy (MRS)
provides a unique perspective on the brain bases of neuropsychiatric disorders. As a context …

Health‐related quality of life and fall risk associated with age‐related body composition changes; sarcopenia, obesity and sarcopenic obesity

ZA Öztürk, İH Türkbeyler, A Abiyev, S Kul… - Internal medicine …, 2018 - Wiley Online Library
Background Sarcopenia, obesity, and sarcopenic obesity are various features of the ageing
process that can cause important health issues. The present study was undertaken to …

Altered spontaneous brain activity in type 2 diabetes: a resting-state functional MRI study

Y Cui, Y Jiao, YC Chen, K Wang, B Gao, S Wen… - Diabetes, 2014 - diabetesjournals.org
Previous research has shown that type 2 diabetes mellitus (T2DM) is associated with an
increased risk of cognitive impairment. Patients with impaired cognition often show …