Identification of tumor antigens with immunopeptidomics

C Chong, G Coukos, M Bassani-Sternberg - Nature Biotechnology, 2022 - nature.com
The identification of actionable tumor antigens is indispensable for the development of
several cancer immunotherapies, including T cell receptor–transduced T cells and patient …

Quantitative proteomic analysis of histone modifications

H Huang, S Lin, BA Garcia, Y Zhao - Chemical reviews, 2015 - ACS Publications
Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

M Gulia-Nuss, AB Nuss, JM Meyer… - Nature …, 2016 - nature.com
Ticks transmit more pathogens to humans and animals than any other arthropod. We
describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors …

[HTML][HTML] ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificity

T Xu, SK Park, JD Venable, JA Wohlschlegel… - Journal of …, 2015 - Elsevier
ProLuCID, a new algorithm for peptide identification using tandem mass spectrometry and
protein sequence databases has been developed. This algorithm uses a three tier scoring …

PEAKS DB: de novo sequencing assisted database search for sensitive and accurate peptide identification

J Zhang, L **n, B Shan, W Chen, M **e… - Molecular & cellular …, 2012 - mcponline.org
Many software tools have been developed for the automated identification of peptides from
tandem mass spectra. The accuracy and sensitivity of the identification software via …

OpenMS–an open-source software framework for mass spectrometry

M Sturm, A Bertsch, C Gröpl, A Hildebrandt… - BMC …, 2008 - Springer
Background Mass spectrometry is an essential analytical technique for high-throughput
analysis in proteomics and metabolomics. The development of new separation techniques …

The Paragon Algorithm, a next generation search engine that uses sequence temperature values and feature probabilities to identify peptides from tandem mass …

IV Shilov, SL Seymour, AA Patel, A Loboda… - Molecular & Cellular …, 2007 - mcponline.org
The Paragon™ Algorithm, a novel database search engine for the identification of peptides
from tandem mass spectrometry data, is presented. Sequence Temperature Values are …

A survey of computational methods and error rate estimation procedures for peptide and protein identification in shotgun proteomics

AI Nesvizhskii - Journal of proteomics, 2010 - Elsevier
This manuscript provides a comprehensive review of the peptide and protein identification
process using tandem mass spectrometry (MS/MS) data generated in shotgun proteomic …

Repeatability and reproducibility in proteomic identifications by liquid chromatography− tandem mass spectrometry

DL Tabb, L Vega-Montoto, PA Rudnick… - Journal of proteome …, 2010 - ACS Publications
The complexity of proteomic instrumentation for LC-MS/MS introduces many possible
sources of variability. Data-dependent sampling of peptides constitutes a stochastic element …

Advances in structure elucidation of small molecules using mass spectrometry

T Kind, O Fiehn - Bioanalytical reviews, 2010 - Springer
The structural elucidation of small molecules using mass spectrometry plays an important
role in modern life sciences and bioanalytical approaches. This review covers different soft …