Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignancies that are
considered as a global health challenge. Despite many progresses in therapeutic methods …

The gastrointestinal tract is covered by mucus that has different properties in the stomach,
small intestine, and colon. The large highly glycosylated gel‐forming mucins MUC 2 and …

Mucins are the main structural components of mucus that create a selective protective
barrier for epithelial surface and also execute wide range of other physiological functions …

BACKGROUND & AIMS: Protein misfolding and endoplasmic reticulum (ER) stress have
been observed in intestinal secretory cells from patients with inflammatory bowel diseases …

The protein disulfide isomerase (PDI) family is a group of multifunctional endoplasmic
reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine …

Objective The optimal therapeutic response in cancer patients is highly dependent upon the
differentiation state of their tumours. Pancreatic ductal adenocarcinoma (PDA) is a lethal …

The endoplasmic reticulum (ER) is the first compartment of secretory pathway. It plays a
major role in ER chaperone-assisted folding and quality control, including post-translational …

Clinical studies have defined the core 'genetic blueprint'of a cancer cell, but this information
does not necessarily predict the cancer phenotype. Signalling hubs that mediate such …

Initially discovered as an estrogen-responsive gene in breast cancer cell lines, anterior
gradient 2 (AGR2) is a developmentally regulated gene belonging to the protein disulfide …

The mechanisms of initiation of pancreatic ductal adenocarcinoma (PDAC) are still largely
unknown. In the present study, we analysed the role of anterior gradient-2 (AGR2) in the …