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Tumor angiogenesis and vascular normalization: alternative therapeutic targets
Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …
Transport of drugs from blood vessels to tumour tissue
The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …
Normalization of the vasculature for treatment of cancer and other diseases
New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
Despite having an abundant number of vessels, tumours are usually hypoxic and nutrient-
deprived because their vessels malfunction. Such abnormal milieu can fuel disease …
deprived because their vessels malfunction. Such abnormal milieu can fuel disease …
[HTML][HTML] A review on CXCR4/CXCL12 axis in oncology: no place to hide
Classical chemotherapeutic anti-cancer treatments induce cell death through DNA damage
by taking advantage of the proliferative behaviour of cancer cells. The more recent approach …
by taking advantage of the proliferative behaviour of cancer cells. The more recent approach …
Vascular microenvironment, tumor immunity and immunotherapy
Z Lamplugh, Y Fan - Frontiers in immunology, 2021 - frontiersin.org
Immunotherapy holds great promise for treating cancer. Nonetheless, T cell-based
immunotherapy of solid tumors has remained challenging, largely due to the lack of …
immunotherapy of solid tumors has remained challenging, largely due to the lack of …
CXCL12 (SDF1α)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Addition of multiple molecularly targeted agents to the existing armamentarium of
chemotherapeutics and radiotherapies represents a significant advance in the management …
chemotherapeutics and radiotherapies represents a significant advance in the management …
PD‐L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy
Pancreatic ductal adenocarcinoma (PDAC) is considered a non‐immunogenic tumor, and
immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) …
immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) …
IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma
Various factors and cellular components in the tumor microenvironment are key drivers
associated with drug resistance in many cancers. Here, we analyzed the factors and …
associated with drug resistance in many cancers. Here, we analyzed the factors and …
Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy
Tumor vessels are characterized by abnormal morphology and hyperpermeability that
together cause inefficient delivery of chemotherapeutic agents. Although vascular …
together cause inefficient delivery of chemotherapeutic agents. Although vascular …