Cardiovascular disorders are the most common cause of mortality in autosomal dominant
polycystic kidney disease (ADPKD). This review considers recent clinical and basic science …

Cardiovascular disease (CVD) is the major cause of mortality in autosomal dominant
polycystic kidney disease (ADPKD) and contributes to significant burden of disease. The …

The hexosamine biosynthetic pathway (HBP) plays critical roles in nutrient sensing, stress
response, and cell growth. However, its contribution to cardiac hypertrophic growth and …

Background: BET (bromodomain and extraterminal) epigenetic reader proteins, in particular
BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in …

Endothelial cells lining the microvasculature are particularly vulnerable to the deleterious
effects of cardiac ischemia/reperfusion (I/R) injury, a susceptibility that is partially mediated …

The disturbance of potassium current in cardiac myocytes caused by potassium channel
dysfunction can lead to cardiac electrophysiological disorders, resulting in associated …

TANGO2-deficiency disorder (TDD) is an autosomal-recessive genetic disease caused by
biallelic loss-of-function variants in the TANGO2 gene. TDD-associated cardiac arrhythmias …

Smoking has been associated with renal disease progression in ADPKD but the underlying
deleterious mechanisms and whether it specifically worsens the cardiac phenotype remain …

Polycystin-1, whose mutation is the most frequent cause of autosomal dominant polycystic
kidney disease, is an extremely large and multi-faceted membrane protein whose primary or …

Abstract Polycystin‐1 (PC1) is a transmembrane protein found in different cell types,
including cardiomyocytes. Alterations in PC1 expression have been linked to mitochondrial …