Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

Roscovitine [CY-202,(R)-Roscovitine, Seliciclib] is a small molecule that inhibits cyclin-
dependent kinases (CDKs) through direct competition at the ATP-binding site. It is a broad …

Molecular glue compounds induce protein–protein interactions that, in the context of a
ubiquitin ligase, lead to protein degradation. Unlike traditional enzyme inhibitors, these …

Cancer is a disorder that rigorously affects the human population worldwide. There is a
steady demand for new remedies to both treat and prevent this life-threatening sickness due …

Tau, the microtubule‐associated protein, forms insoluble filaments that accumulate as
neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under …

The first example of transition metal-catalyzed meta-selective CAr–H nitration of arenes is
described. With the use of Ru3 (CO) 12 as the catalyst and Cu (NO3) 2· 3H2O as the nitro …

With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …

The circadian timing system is composed of molecular clocks, which drive 24-h changes in
xenobiotic metabolism and detoxification, cell cycle events, DNA repair, apoptosis, and …

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

The amyloid cascade hypothesis has always been a research focus in the therapeutic field
of Alzheimer's disease (AD) since it was put forward. Numerous researchers attempted to …