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[HTML][HTML] Biomechanics of the human intervertebral disc: a review of testing techniques and results
Many experimental testing techniques have been adopted in order to provide an
understanding of the biomechanics of the human intervertebral disc (IVD). The aim of this …
understanding of the biomechanics of the human intervertebral disc (IVD). The aim of this …
[HTML][HTML] The proteolysis of ECM in intervertebral disc degeneration
Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs
throughout the human life span and is a major cause of lower back pain. Better elucidation …
throughout the human life span and is a major cause of lower back pain. Better elucidation …
Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc …
J Wu, Y Chen, Z Liao, H Liu, S Zhang, D Zhong, X Qiu… - Molecular Therapy, 2022 - cell.com
Abnormal mechanical load is a main risk factor of intervertebral disc degeneration (IDD),
and cellular senescence is a pathological change in IDD. In addition, extracellular matrix …
and cellular senescence is a pathological change in IDD. In addition, extracellular matrix …
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx
Z **ang, P Zhang, C Jia, R Xu, D Cao, Z Xu, T Lu, J Liu… - Bone research, 2024 - nature.com
To date, several molecules have been found to facilitate iron influx, while the types of iron
influx channels remain to be elucidated. Here, Piezo1 channel was identified as a key iron …
influx channels remain to be elucidated. Here, Piezo1 channel was identified as a key iron …
Molecular mechanisms of biological aging in intervertebral discs
NV Vo, RA Hartman, PR Patil… - Journal of …, 2016 - Wiley Online Library
Advanced age is the greatest risk factor for the majority of human ailments, including spine‐
related chronic disability and back pain, which stem from age‐associated intervertebral disc …
related chronic disability and back pain, which stem from age‐associated intervertebral disc …
Lumbar degenerative disease part 1: anatomy and pathophysiology of intervertebral discogenic pain and radiofrequency ablation of basivertebral and sinuvertebral …
HS Kim, PH Wu, IT Jang - International journal of molecular sciences, 2020 - mdpi.com
Degenerative disc disease is a leading cause of chronic back pain in the aging population in
the world. Sinuvertebral nerve and basivertebral nerve are postulated to be associated with …
the world. Sinuvertebral nerve and basivertebral nerve are postulated to be associated with …
[HTML][HTML] Materials for the spine: anatomy, problems, and solutions
BA Frost, S Camarero-Espinosa, EJ Foster - Materials, 2019 - mdpi.com
Disc degeneration affects 12% to 35% of a given population, based on genetics, age,
gender, and other environmental factors, and usually occurs in the lumbar spine due to …
gender, and other environmental factors, and usually occurs in the lumbar spine due to …
Mechanosensitive ion channel Piezo1 activated by matrix stiffness regulates oxidative stress‐induced senescence and apoptosis in human intervertebral disc …
B Wang, W Ke, K Wang, G Li, L Ma, S Lu… - Oxidative medicine …, 2021 - Wiley Online Library
Mechanical stimulation plays a crucial part in the development of intervertebral disc
degeneration (IDD). Extracellular matrix (ECM) stiffness, which is a crucial mechanical …
degeneration (IDD). Extracellular matrix (ECM) stiffness, which is a crucial mechanical …
Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its …
JC Iatridis, SB Nicoll, AJ Michalek, BA Walter… - The spine journal, 2013 - Elsevier
BACKGROUND CONTEXT: Degeneration and injuries of the intervertebral disc (IVD) result
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …
Fundamental biomechanics of the spine—what we have learned in the past 25 years and future directions
TR Oxland - Journal of biomechanics, 2016 - Elsevier
Since the publication of the 2nd edition of White and Panjabi׳ s textbook, Clinical
Biomechanics of the Spine in 1990, there has been considerable research on the …
Biomechanics of the Spine in 1990, there has been considerable research on the …