The primary aim of “omic” technologies is the nontargeted identification of all gene products
(transcripts, proteins, and metabolites) present in a specific biological sample. By their …

A central focus of postgenomic research will be to understand how cellular phenomena
arise from the connectivity of genes and proteins. This connectivity generates molecular …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Transcriptional regulation is an inherently noisy process. The origins of this stochastic
behavior can be traced to the random transitions among the discrete chemical states of …

Recent advances in cell-free synthetic biology have given rise to gene circuit-based sensors
with the potential to provide decentralized and low-cost molecular diagnostics. However, it …

One of the important challenges in the emerging field of synthetic biology is designing
artificial networks that achieve coordinated behavior in cell communities. Here we present a …

Remarkable progress in genomic research is leading to a complete map of the building
blocks of biology. Knowledge of this map is, in turn, setting the stage for a fundamental …

Promoters are DNA regulatory elements located directly upstream or at the 5'end of the
transcription initiation site (TSS), which are in charge of gene transcription initiation. With the …

The construction of synthetic biochemical circuits from simple components illuminates how
complex behaviors can arise in chemistry and builds a foundation for future biological …

The deduction of phenotypic cellular responses from the structure and behavior of complex
gene regulatory networks is one of the defining challenges of systems biology. This goal will …