SARS-CoV-2 pathogenesis
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …
Organoids
Z Zhao, X Chen, AM Dowbaj, A Sljukic… - Nature Reviews …, 2022 - nature.com
Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …
aspects of the complex structure and function of the corresponding in vivo tissue. They can …
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
Abstract The SARS-CoV-2 Omicron BA. 1 variant emerged in 2021 and has multiple
mutations in its spike protein. Here we show that the spike protein of Omicron has a higher …
mutations in its spike protein. Here we show that the spike protein of Omicron has a higher …
Human organoids: model systems for human biology and medicine
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …
made it challenging to address questions that are specific to the understanding of human …
Engineering organoids
Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …
enormous interest for modelling tissue development and disease, and for personalized …
SARS-CoV-2 productively infects human gut enterocytes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus
disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the …
disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the …
Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy
The December 2019 outbreak of a novel respiratory virus, SARS-CoV-2, has become an
ongoing global pandemic due in part to the challenge of identifying symptomatic …
ongoing global pandemic due in part to the challenge of identifying symptomatic …
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …
Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
We identified an emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples …
variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples …
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis
Epithelial organoids, such as those derived from stem cells of the intestine, have great
potential for modelling tissue and disease biology,,–. However, the approaches that are …
potential for modelling tissue and disease biology,,–. However, the approaches that are …