Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

Temperature profoundly affects macromolecular function, particularly in proteins with
temperature sensitivity,. However, its impact is often overlooked in biophysical studies that …

Pain therapy has remained conceptually stagnant since the opioid crisis, which highlighted
the dangers of treating pain with opioids. An alternative addiction-free strategy to …

Crosstalk between ion channels and small GTPases is critical during homeostasis and
disease, but little is known about the structural underpinnings of these interactions. TRPV4 is …

The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular
transducer responsible for the cool sensation elicited by menthol and cold in mammals …

TRPV3 represents both temperature-and ligand-activated transient receptor potential (TRP)
channel. Physiologically relevant opening of TRPV3 channels by heat has been captured …

BACKGROUND Chronic pain is a debilitating illness with currently limited therapy, in part
due to difficulties in translating treatments derived from animal models to patients. The …

Transient receptor potential (TRP) ion channels are sophisticated signaling machines that
detect a wide variety of environmental and physiological signals. Every cell in the body …