Ischemic stroke, a major cause of mortality in the United States, often contributes to
disruption of the blood-brain barrier (BBB). The BBB along with its supportive cells …

Neutrophils have key roles in ischemic brain injury, thrombosis, and atherosclerosis. As
such, neutrophils are of great interest as targets to treat and prevent ischemic stroke. After …

Circadian biology modulates almost all aspects of mammalian physiology, disease, and
response to therapies. Emerging data suggest that circadian biology may significantly affect …

After stroke, peripheral immune cells are activated and these systemic responses may
amplify brain damage, but how the injured brain sends out signals to trigger systemic …

Exosomes are a type of extracellular vesicle (EV) with diameters of 30–150 nm secreted by
most of the cells into the extracellular spaces and can alter the microenvironment through …

Neutrophils are implicated in numerous inflammatory diseases, and especially in acute
ischemic stroke (AIS). The unchecked migration of neutrophils into cerebral ischemic …

Objective Bridging the gap between experimental stroke and patients by ischemic blood
probing during the hyperacute stage of vascular occlusion is crucial to assess the role of …

Platelet-neutrophil interactions significantly contribute to the pathophysiology of ischemic
stroke brain injury. Better understanding the mechanisms behind their formation and the …

Objective In acute cerebral ischemia, circulating neutrophil count and neutrophil-to-
lymphocyte ratio (NLR) are positively associated with stroke severity and worse outcomes …

Acute stroke causes complex, pathological, and systemic responses that have not been
treatable by any single medication. In this study, using a murine transient middle cerebral …