The therapeutic utility of antibodies and their derivatives is achieved by various means. The
FDA has approved several targeted antibodies that disrupt signaling of various growth factor …

Purpose The aim of the present paper is to review the role of HER2 antibodies, affibodies
and nanobodies as vehicles for imaging and therapy approaches in breast cancer, including …

Immunotherapy is becoming the mainstay for treatment of a variety of malignancies, but only
a subset of patients responds to treatment. Tumor-infiltrating CD8-positive (CD8+) T …

The programmed death protein (PD-1) and its ligand (PD-L1) play critical roles in a
checkpoint pathway cancer cells exploit to evade the immune system. A same-day PET …

Nanobodies are the smallest fully functional antigen-binding antibody fragments possessing
ideal properties as probes for molecular imaging. In this study we labeled the anti–human …

Recent developments and improvements of multimodal imaging methods for use in animal
research have substantially strengthened the options of in vivo visualization of cancer …

Identification of cancer cell–surface biomarkers and advances in antibody engineering have
led to a sharp increase in the development of therapeutic antibodies. These same advances …

Antibodies have long been recognised as potent vectors for carrying diagnostic medical
radionuclides, contrast agents and optical probes to diseased tissue for imaging. The area of …

Tumor-associated macrophages constitute a major component of the stroma of solid tumors,
encompassing distinct subpopulations with different characteristics and functions. We aimed …

We conducted a phase I dose-escalation study with 89Zr-desferrioxamine-IAB2M (89Zr-
IAB2M), an anti–prostate-specific membrane antigen minibody, in patients with metastatic …