Gradients in industrial bioreactors have attracted substantial research attention since
exposure to fluctuating environmental conditions has been shown to lead to changes in the …

Bioprocess scale-up is a critical step in process development. However, loss of production
performance upon scaling-up, including reduced titer, yield, or productivity, has often been …

This multiauthor review article aims to bring readers up to date with some of the current
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …

Biosynthesis enables renewable production of manifold compounds, yet often biosynthetic
performance must be improved for it to be economically feasible. Nongenetic, cell-to-cell …

Predictive microbiology in foods is a research area within food microbiology intended to
provide mathematical models to predict microbial behavior in food environments. Although …

Microorganisms in nature form diverse communities that dynamically change in structure
and function in response to environmental variations. As a complex adaptive system …

Highlights•Microfluidics offers unique opportunities for bioprocess development.•
Environmental conditions can be precisely controlled on single-cell level.•Single-cell …

Single-cell analysis (SCA) has been increasingly recognized as the key technology for the
elucidation of cellular functions, which are not accessible from bulk measurements on the …

Advanced control strategies are well established in chemical, pharmaceutical, and food
processing industries. Over the past decade, the application of these strategies is being …

Weak-acid preservatives, such as sorbic acid and acetic acid, are used in many low pH
foods to prevent spoilage by fungi. The spoilage yeast Zygosaccharomyces bailii is …