Considering the fundamental role of protein kinases in the mechanism of protein
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …

The proto-oncogenic protein, c-KIT, plays a crucial role in regulating cellular transformation
and differentiation processes, such as proliferation, survival, adhesion, and chemotaxis. The …

Purpose The prognosis of patients with metastatic GIST and imatinib-sensitive primary
mutations has significantly improved. However, limited data are available to inform patients …

Introduction Approximately 90% of gastrointestinal stromal tumors (GISTs) are driven by
activating mutations in receptor tyrosine-kinases KIT or PDGFRA. Despite the outstanding …

Background: The majority of GIST are driven by constitutively activated KIT/PDGFRA kinases
and are susceptible to treatment with tyrosine kinase inhibitors. During treatment, most of …

Stem cell factor receptor (C-KIT) or platelet-derived growth factor receptor α (PDGFRα) gene
mutations have been identified as oncogenic drivers for most gastrointestinal stromal tumors …

Purpose: The majority of gastrointestinal stromal tumors (GIST) are driven by constitutively
activated KIT/PDGFRA kinases and are susceptible to treatment with tyrosine kinase …

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal-derived tumors
of the gastrointestinal tract. Tyrosine kinase inhibitors (TKIs) are the cornerstone of GIST …

BACKGROUND RESULTS Patrick Schöffski1, Michael Heinrich2, Jonathan Trent3, César
Serrano4, Sebastian Bauer5, Margaret von Mehren6, George Demetri7, Nick Lydon7, Jaap …