Synergistic effects of heavy metals and pesticides in living systems
There is a widespread repeated exposure of the population to the pesticides and heavy
metals of occupational and environmental origin. Such population is forced to undergo …
metals of occupational and environmental origin. Such population is forced to undergo …
Chemotherapy of schistosomiasis: present and future
CR Caffrey - Current opinion in chemical biology, 2007 - Elsevier
Schistosomiasis is a chronic parasitic disease in tropical and subtropical regions and is
associated with a variety of clinical syndromes that may lead to severe morbidity. Over the …
associated with a variety of clinical syndromes that may lead to severe morbidity. Over the …
A Systematically Improved High Quality Genome and Transcriptome of the Human Blood Fluke Schistosoma mansoni
Schistosomiasis is one of the most prevalent parasitic diseases, affecting millions of people
in develo** countries. Amongst the human-infective species, Schistosoma mansoni is also …
in develo** countries. Amongst the human-infective species, Schistosoma mansoni is also …
Identification of oxadiazoles as new drug leads for the control of schistosomiasis
Abstract Treatment for schistosomiasis, which is responsible for more than 280,000 deaths
annually, depends almost exclusively on praziquantel. Millions of people are treated …
annually, depends almost exclusively on praziquantel. Millions of people are treated …
Proteomic analysis of Schistosoma mansoni egg secretions
CL Cass, JR Johnson, LL Califf, T Xu… - Molecular and …, 2007 - Elsevier
Schistosomiasis remains a largely neglected, global health problem. The morbid pathology
of the disease stems from the host's inflammatory response to parasite eggs trapped in host …
of the disease stems from the host's inflammatory response to parasite eggs trapped in host …
Tuning of peroxiredoxin catalysis for various physiological roles
Peroxiredoxins (Prxs) make up an ancient family of enzymes that are the predominant
peroxidases for nearly all organisms and play essential roles in reducing hydrogen …
peroxidases for nearly all organisms and play essential roles in reducing hydrogen …
Immunological and biochemical interplay between cytokines, oxidative stress and schistosomiasis
The host–parasite schistosome relationship relies heavily on the interplay between the
strategies imposed by the schistosome worm and the defense mechanisms the host uses to …
strategies imposed by the schistosome worm and the defense mechanisms the host uses to …
Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis
CA Bulman, CM Bidlow, S Lustigman… - PLoS neglected …, 2015 - journals.plos.org
Two major human diseases caused by filariid nematodes are onchocerciasis, or river
blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin …
blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin …
Schistosoma genomics: new perspectives on schistosome biology and host-parasite interaction
ZG Han, PJ Brindley, SY Wang… - Annual review of …, 2009 - annualreviews.org
Schistosomiasis, caused mainly by Schistosoma japonicum, S. mansoni, and S.
hematobium, remains one of the most prevalent and serious parasitic diseases worldwide …
hematobium, remains one of the most prevalent and serious parasitic diseases worldwide …
Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin
F Saccoccia, P Di Micco, G Boumis, M Brunori, I Koutris… - Structure, 2012 - cell.com
Cys peroxiredoxins (Prxs) play two different roles depending on the physiological status of
the cell. They are thioredoxin-dependent peroxidases under low oxidative stress and ATP …
the cell. They are thioredoxin-dependent peroxidases under low oxidative stress and ATP …