Proteins are one of the most versatile modular assembling systems in nature.
Experimentally, more than 110 000 protein structures have been identified and more are …

Naturally occurring proteins comprise a special subset of all plausible sequences and
structures selected through evolution. Simulating protein evolution with simplified and all …

Gene duplication is postulated to have played a major role in the evolution of biological
novelty. Here, gene duplication is examined across levels of biological organization in an …

Many species of bacteria can spread over a moist surface via a particular form of collective
motion known as" surface swarming". This form of motility is typically studied by inoculating …

Understanding the observed variability in the number of homologs of a gene is a very
important unsolved problem that has broad implications for research into coevolution of …

The observed distribution of protein structures can give us important clues about the
underlying evolutionary process, imposing important constraints on possible models. The …

Efforts in whole-genome sequencing and structural proteomics start to provide a global view
of the protein universe, the set of existing protein structures and sequences. However …

Homology modeling is a powerful tool for predicting a protein's structure. This approach is
successful because proteins whose sequences are only 30% identical still adopt the same …

It has been known for some time that many proteins are marginally stable. This has inspired
several explanations. Having noted that the functionality of many enzymes is correlated with …

Proteins are the workhorse of life. They are the building infrastructure of living systems; they
are the most efficient molecular machines known, and their enzymatic activity is still …