T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …

Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder. The
pathogenesis of IBD is not yet clear. Studies have shown that the imbalance between T …

Chronic antigen exposure during viral infection or cancer promotes an exhausted T cell
(Tex) state with reduced effector function. However, whether all antigen-specific T cell clones …

Chimeric antigen receptors (CARs) are synthetic receptors that target and reprogram T cells
to acquire augmented antitumor properties. CD19-specific CARs that comprise CD28 and …

Abstract Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …

CD4+ T helper (Th) cells play central roles in immunity in health and disease. While much is
known about the effector function of Th cells in combating pathogens and promoting …

Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell
development and T memory formation and encompasses new functions in the regulation of …

Inflammatory bowel disease (IBD) refers to a gamut of disorders that are characterized by
chronic intestinal inflammation, including ulcerative colitis (UC) and Crohn's disease (CD) …

Immune protection and lasting memory are accomplished through the generation of
phenotypically and functionally distinct CD8 T cell subsets. Understanding how these …

Chimeric antigen receptors (CARs) link an antigen recognition domain to intracellular
signaling domains to redirect T cell specificity and function. T cells expressing CARs with …