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Immune checkpoint inhibitors in cancer therapy
The discovery of immune checkpoint proteins such as PD-1/PDL-1 and CTLA-4 represents a
significant breakthrough in the field of cancer immunotherapy. Therefore, humanized …
significant breakthrough in the field of cancer immunotherapy. Therefore, humanized …
CRISPR in cancer biology and therapy
Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …
transforming biomedical research and providing entirely new approaches for dissecting all …
Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons
The main breakthrough in tumor immunotherapy was the discovery of immune checkpoint
(IC) proteins, which act as a potent suppressor of the immune system by a myriad of …
(IC) proteins, which act as a potent suppressor of the immune system by a myriad of …
Characterization and visualization of tandem repeats at genome scale
Tandem repeat (TR) variation is associated with gene expression changes and numerous
rare monogenic diseases. Although long-read sequencing provides accurate full-length …
rare monogenic diseases. Although long-read sequencing provides accurate full-length …
Hot and cold tumors: Immunological features and the therapeutic strategies
L Wang, H Geng, Y Liu, L Liu, Y Chen, F Wu, Z Liu… - MedComm, 2023 - Wiley Online Library
Abstract The “hotness” or “coldness” of the tumors are determined by the information of the
cancer cells themselves, tumor immune characteristics, tumor microenvironment, and …
cancer cells themselves, tumor immune characteristics, tumor microenvironment, and …
mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and
apoptosis by participating in multiple signaling pathways in the body. Studies have shown …
apoptosis by participating in multiple signaling pathways in the body. Studies have shown …
Artificial intelligence in oncology: current landscape, challenges, and future directions
Artificial intelligence (AI) in oncology is advancing beyond algorithm development to
integration into clinical practice. This review describes the current state of the field, with a …
integration into clinical practice. This review describes the current state of the field, with a …
TMB or not TMB as a biomarker: That is the question
Immune checkpoint inhibitors (ICIs) have revolutionized the landscape of therapeutic
options for many cancers. These treatments have demonstrated improved efficacy and often …
options for many cancers. These treatments have demonstrated improved efficacy and often …
Advances in artificial intelligence to predict cancer immunotherapy efficacy
Tumor immunotherapy, particularly the use of immune checkpoint inhibitors, has yielded
impressive clinical benefits. Therefore, it is critical to accurately screen individuals for …
impressive clinical benefits. Therefore, it is critical to accurately screen individuals for …
Current targeted therapy for metastatic colorectal cancer
T Ohishi, MK Kaneko, Y Yoshida, A Takashima… - International Journal of …, 2023 - mdpi.com
Colorectal cancer (CRC) is the third most common type of cancer and the second leading
cause of cancer deaths worldwide. Surgery or surgery plus radiotherapy and/or …
cause of cancer deaths worldwide. Surgery or surgery plus radiotherapy and/or …