Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

Background In this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the
recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR …

The first cancer-targeted microRNA (miRNA) drug—MRX34, a liposome-based miR-34
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …

Purpose Naturally occurring tumor suppressor microRNA-34a (miR-34a) downregulates the
expression of> 30 oncogenes across multiple oncogenic pathways, as well as genes …

During the course of malignant cancer progression, neoplastic cells undergo dynamic and
reversible transitions between multiple phenotypic states, the extremes of which are defined …

With the advent of next generation sequencing techniques a previously unknown world of
non-coding RNA molecules have been discovered. Non-coding RNA transcripts likely …

Epigenetic and genetic alterations have long been thought of as two separate mechanisms
participating in carcinogenesis. A recent outcome of whole exome sequencing of thousands …

MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non …