Traditional Chinese medicine (TCM) has used herbal remedies for more than 2,000 years.
The use of complimentary therapies has increased dramatically during the last years …

Fructose is a natural monosaccharide broadly used in modern society. Over the past few
decades, epidemiological studies have demonstrated that high fructose intake is an …

Scope Kefir consumption inhibits the development of obesity and non‐alcoholic fatty liver
disease (NALFD) in mice fed 60% high‐fat diet (HFD). To identify the key contributor of this …

Enolase is a component of the glycolysis pathway and a “moonlighting” protein, with
important roles in diverse cellular processes that are not related to its function in glycolysis …

The discovery of effective and safe antiobesity agents remains a challenging yet promising
field. Our previous studies identified Bouchardatine derivatives as potential antiobesity …

Background and Purpose Matrine is a small molecule drug used in humans for the treatment
of chronic viral infections and tumours in the liver with little adverse effects. The present …

Background: Accumulating experimental data supports the capacity of natural compounds to
intervene in complicated molecular pathways underlying the pathogenesis of certain human …

Aim: Oxymatrine (OMT) is the major quinolizidine alkaloid extracted from the root of Sophora
flavescens Ait (the Chinese herb Kushen) and exhibits diverse pharmacological actions. In …

Based on the co-crystal structures of LXRβ and its agonists (spiro [pyrrolidine-3, 3′-
oxindole] derivatives) discovered by us previously, we designed and synthesized a …

Four new pterosin sesquiterpenoids (1–4), a new ent-kaurane diterpenoid (17), and 18
known compounds were isolated from the aerial parts of Pteris cretica L. The structures of …