A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

The process of mitosis is a validated point of intervention in cancer therapy and a variety of
anti-mitotic drugs are successfully being used in the clinic. To date, all approved antimitotics …

The process of cell division or mitosis is highly complex and tightly regulated. During this
phase of the cell cycle two identical copies of DNA are completely separated by the …

Kinesin superfamily proteins (KIFs) comprise a family of molecular motors that transport
membranous organelles and protein complexes in a microtubule-and ATP-dependent …

Kinesin spindle protein (KSP), a member of the kinesin superfamily of microtubule-based
motors, plays a critical role in mitosis as it mediates centrosome separation and bipolar …

The spindle midzone—composed of antiparallel microtubules, microtubule-associated
proteins (MAPs), and motors—is the structure responsible for microtubule organization and …

Kinesin‐5 motors fulfil essential roles in mitotic spindle morphogenesis and dynamics as
slow, processive microtubule (MT) plus‐end directed motors. The Saccharomyces …

Chromosome segregation during mitosis depends upon Kinesin-5 motors, which display a
conserved, bipolar homotetrameric organization consisting of two motor dimers at opposite …

The segregation of genetic material during mitosis is coordinated by the mitotic spindle,
whose action depends upon the polarity patterns of its microtubules (MTs)[1, 2] …

We used antibody microinjection and genetic manipulations to dissect the various roles of
the homotetrameric kinesin-5, KLP61F, in astral, centrosome-controlled Drosophila embryo …