Seven mobile oxazolidinone resistance genes, including cfr, cfr (B), cfr (C), cfr (D), cfr (E),
optrA, and poxtA, have been identified to date. The cfr genes code for 23S rRNA methylases …

The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the
treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind …

Antimicrobial resistance (AMR) remains a major global public health crisis. The food animal
industry will face escalating challenges to increase productivity while minimizing AMR, since …

Enterococcus species are natural inhabitants of the intestinal tract in humans and animals,
and due to their ubiquity in human and animal feces and their persistence in the …

Linezolid is considered a last resort drug in treatment of severe infections caused by Gram-
positive pathogens, resistant to other antibiotics, such as vancomycin-resistant enterococci …

Background The use of antimicrobials in layer poultry production for improved production,
growth promotion, prophylaxis and treatment purposes has contributed to the development …

Objectives This study evaluated the oxazolidinone resistance mechanisms among a global
collection of enterococcal clinical isolates. The epidemiology of optrA-carrying isolates and …

Staphylococcus capitis is divided into two subspecies, S. capitis subsp. ureolyticus
(renamed urealyticus in 1992; ATCC 49326) and S. capitis subsp. capitis (ATCC 27840) …

Linezolid-resistant Enterococcus faecalis (LREfs) carrying optrA are increasingly reported
globally from multiple sources, but we lack a comprehensive analysis of human and animal …

The number of linezolid-resistant Enterococcus spp. isolates received by the National
Reference Centre for Staphylococci and Enterococci in Germany has been increasing since …