Genotype× environment interactions in gene regulation and complex traits

C Boye, S Nirmalan, A Ranjbaran, F Luca - Nature Genetics, 2024 - nature.com
Genotype× environment interactions (GxE) have long been recognized as a key mechanism
underlying human phenotypic variation. Technological developments over the past 15 years …

Gene–environment interactions in human health

E Herrera-Luis, K Benke, H Volk… - Nature Reviews …, 2024 - nature.com
Gene–environment interactions (G× E), the interplay of genetic variation with environmental
factors, have a pivotal impact on human complex traits and diseases. Statistically, G× E can …

Single-cell eQTL models reveal dynamic T cell state dependence of disease loci

A Nathan, S Asgari, K Ishigaki, C Valencia, T Amariuta… - Nature, 2022 - nature.com
Non-coding genetic variants may cause disease by modulating gene expression. However,
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …

A compressed variance component mixed model for detecting QTNs and QTN-by-environment and QTN-by-QTN interactions in genome-wide association studies

M Li, YW Zhang, ZC Zhang, Y **ang, MH Liu, YH Zhou… - Molecular Plant, 2022 - cell.com
Although genome-wide association studies are widely used to mine genes for quantitative
traits, the effects to be estimated are confounded, and the methodologies for detecting …

Breeding and genomic approaches towards development of fusarium wilt resistance in chickpea

RK Yadav, MK Tripathi, S Tiwari, N Tripathi, R Asati… - Life, 2023 - mdpi.com
Chickpea is an important leguminous crop with potential to provide dietary proteins to both
humans and animals. It also ameliorates soil nitrogen through biological nitrogen fixation …

Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies

N Cai, KW Choi, EI Fried - Human molecular genetics, 2020 - academic.oup.com
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …

Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank

H Wang, F Zhang, J Zeng, Y Wu, KE Kemper, A Xue… - Science …, 2019 - science.org
Genotype-by-environment interaction (GEI) is a fundamental component in understanding
complex trait variation. However, it remains challenging to identify genetic variants with GEI …

Sociology, genetics, and the coming of age of sociogenomics

MC Mills, FC Tropf - Annual review of sociology, 2020 - annualreviews.org
Recent years have seen the birth of sociogenomics via the infusion of molecular genetic
data. We chronicle the history of genetics, focusing particularly on post-2005 genome-wide …

Genome-wide association study identifies a gene responsible for temperature-dependent rice germination

H Yoshida, K Hirano, K Yano, F Wang, M Mori… - Nature …, 2022 - nature.com
Environment is an important determinant of agricultural productivity; therefore, crops have
been bred with traits adapted to their environment. It is assumed that the physiology of seed …

[HTML][HTML] An integrated framework reinstating the environmental dimension for GWAS and genomic selection in crops

X Li, T Guo, J Wang, WA Bekele, S Sukumaran… - Molecular Plant, 2021 - cell.com
Identifying mechanisms and pathways involved in gene–environment interplay and
phenotypic plasticity is a long-standing challenge. It is highly desirable to establish an …