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Genotype× environment interactions in gene regulation and complex traits
Genotype× environment interactions (GxE) have long been recognized as a key mechanism
underlying human phenotypic variation. Technological developments over the past 15 years …
underlying human phenotypic variation. Technological developments over the past 15 years …
Gene–environment interactions in human health
Gene–environment interactions (G× E), the interplay of genetic variation with environmental
factors, have a pivotal impact on human complex traits and diseases. Statistically, G× E can …
factors, have a pivotal impact on human complex traits and diseases. Statistically, G× E can …
Single-cell eQTL models reveal dynamic T cell state dependence of disease loci
Non-coding genetic variants may cause disease by modulating gene expression. However,
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …
A compressed variance component mixed model for detecting QTNs and QTN-by-environment and QTN-by-QTN interactions in genome-wide association studies
M Li, YW Zhang, ZC Zhang, Y **ang, MH Liu, YH Zhou… - Molecular Plant, 2022 - cell.com
Although genome-wide association studies are widely used to mine genes for quantitative
traits, the effects to be estimated are confounded, and the methodologies for detecting …
traits, the effects to be estimated are confounded, and the methodologies for detecting …
Breeding and genomic approaches towards development of fusarium wilt resistance in chickpea
Chickpea is an important leguminous crop with potential to provide dietary proteins to both
humans and animals. It also ameliorates soil nitrogen through biological nitrogen fixation …
humans and animals. It also ameliorates soil nitrogen through biological nitrogen fixation …
Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank
Genotype-by-environment interaction (GEI) is a fundamental component in understanding
complex trait variation. However, it remains challenging to identify genetic variants with GEI …
complex trait variation. However, it remains challenging to identify genetic variants with GEI …
Sociology, genetics, and the coming of age of sociogenomics
Recent years have seen the birth of sociogenomics via the infusion of molecular genetic
data. We chronicle the history of genetics, focusing particularly on post-2005 genome-wide …
data. We chronicle the history of genetics, focusing particularly on post-2005 genome-wide …
Genome-wide association study identifies a gene responsible for temperature-dependent rice germination
H Yoshida, K Hirano, K Yano, F Wang, M Mori… - Nature …, 2022 - nature.com
Environment is an important determinant of agricultural productivity; therefore, crops have
been bred with traits adapted to their environment. It is assumed that the physiology of seed …
been bred with traits adapted to their environment. It is assumed that the physiology of seed …
[HTML][HTML] An integrated framework reinstating the environmental dimension for GWAS and genomic selection in crops
Identifying mechanisms and pathways involved in gene–environment interplay and
phenotypic plasticity is a long-standing challenge. It is highly desirable to establish an …
phenotypic plasticity is a long-standing challenge. It is highly desirable to establish an …