Next-generation sequencing has allowed identification of millions of somatic mutations and
epigenetic changes in cancer cells. A key challenge in interpreting cancer genomes and …

High-throughput experimental technologies are generating increasingly massive and
complex genomic data sets. The sheer enormity and heterogeneity of these data threaten to …

Numerous large-scale genomic studies of matched tumor-normal samples have established
the somatic landscapes of most cancer types. However, the downstream analysis of data …

Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …

Abstract The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis
methods to identify somatic variants across thousands of tumours. Here we present data and …

Cancers exhibit extensive mutational heterogeneity, and the resulting long-tail phenomenon
complicates the discovery of genes and pathways that are significantly mutated in cancer …

Large-scale integrated cancer genome characterization efforts including the cancer genome
atlas and the cancer cell line encyclopedia have created unprecedented opportunities to …

Large efforts dedicated to detect somatic alterations across tumor genomes/exomes are
expected to produce significant improvements in precision cancer medicine. However, high …

We report the first large-scale exome-wide analysis of the combined germline–somatic
landscape in ovarian cancer. Here we analyse germline and somatic alterations in 429 …

Complex diseases are caused by a combination of genetic and environmental factors.
Uncovering the molecular pathways through which genetic factors affect a phenotype is …