Spatial multi-omics: deciphering technological landscape of integration of multi-omics and its applications

X Liu, T Peng, M Xu, S Lin, B Hu, T Chu, B Liu… - Journal of Hematology & …, 2024 - Springer
The emergence of spatial multi-omics has helped address the limitations of single-cell
sequencing, which often leads to the loss of spatial context among cell populations …

Spatial transcriptomics: a powerful tool in disease understanding and drug discovery

J Cao, C Li, Z Cui, S Deng, T Lei, W Liu, H Yang… - …, 2024 - pmc.ncbi.nlm.nih.gov
Recent advancements in modern science have provided robust tools for drug discovery. The
rapid development of transcriptome sequencing technologies has given rise to single-cell …

Spatial transcriptomics: recent developments and insights in respiratory research

WJ Wang, LX Chu, LY He, MJ Zhang, KT Dang… - Military Medical …, 2023 - Springer
The respiratory system's complex cellular heterogeneity presents unique challenges to
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …

Navigating the landscapes of spatial transcriptomics: How computational methods guide the way

R Li, X Chen, X Yang - Wiley Interdisciplinary Reviews: RNA, 2024 - Wiley Online Library
Spatially resolved transcriptomics has been dramatically transforming biological and
medical research in various fields. It enables transcriptome profiling at single‐cell, multi …

The role of microglia heterogeneity in synaptic plasticity and brain disorders: Will sequencing shed light on the discovery of new therapeutic targets?

Y You, Z Chen, WW Hu - Pharmacology & Therapeutics, 2024 - Elsevier
Microglia play a crucial role in interacting with neuronal synapses and modulating synaptic
plasticity. This function is particularly significant during postnatal development, as microglia …

Spatial transcriptomics data and analytical methods: an updated perspective

S Khan, JJ Kim - Drug Discovery Today, 2024 - Elsevier
Spatial transcriptomics (ST) is a newly emerging field that integrates high-resolution imaging
and transcriptomic data to enable the high-throughput analysis of the spatial localization of …

A practical guide to spatial transcriptomics

L Valihrach, D Zucha, P Abaffy, M Kubista - Molecular Aspects of Medicine, 2024 - Elsevier
Spatial transcriptomics is revolutionizing modern biology, offering researchers an
unprecedented ability to unravel intricate gene expression patterns within tissues. From …

Single-cell and spatial transcriptomics reveal a high glycolysis B cell and tumor-associated macrophages cluster correlated with poor prognosis and exhausted …

L Dai, G Fan, T **e, L Li, L Tang, H Chen, Y Shi… - Biomarker …, 2024 - Springer
Background Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy
characterized by varied responses to treatment and prognoses. Understanding the …

Spatial transcriptome‐wide profiling of small cell lung cancer reveals intra‐tumoral molecular and subtype heterogeneity

Z Zhang, X Sun, Y Liu, Y Zhang, Z Yang… - Advanced …, 2024 - Wiley Online Library
Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid
growth and early metastasis and is susceptible to treatment resistance and recurrence …

STAB2: an updated spatio-temporal cell atlas of the human and mouse brain

YT Yang, Z Gan, J Zhang, X Zhao, Y Yang… - Nucleic Acids …, 2024 - academic.oup.com
The brain is constituted of heterogeneous types of neuronal and non-neuronal cells, which
are organized into distinct anatomical regions, and show precise regulation of gene …