Despite the progress that has occurred in recent years in the development of therapies to
treat painful and inflammatory diseases, there is still a need for effective and potent …

Neuropathic pain (NP) is a chronic condition that results from a lesion or disease of the
nervous system, greatly impacting patients' quality of life. Current pharmacotherapy options …

Diabetes mellitus (DM) affects bone metabolism and leads to osteoporosis; however, its
pathogenetic mechanisms remain unknown. We found that high glucose (HG) conditions …

A novel polysaccharide from Siraitia grosvenorii residues (SGP, molecular weight 1.93× 10
3 KDa) was isolated and purified. SGP was composed of α-L-Arabinose, α-D-Mannose, α-d …

Polyunsaturated fatty acids (PUFA) are fundamental building materials for cells and play
crucial function as signaling molecules. When PUFA are used as substrates for non …

Oxidative stress damage can lead to premature skin aging or age‐related skin disorders.
Therefore, strategies to improve oxidative stress‐induced aging are needed to protect the …

We now appreciate that the mechanism of resolution depends on an active and time-
dependent biosynthetic shift from pro-inflammatory to pro-resolution mediators, the so-called …

Acute exposure to UVB irradiation causes skin inflammation and oxidative stress, and long-
term exposure to UVB irradiation may lead to carcinogenesis. Our organism has …

UV irradiation-induced oxidative stress and inflammation contribute to the development of
skin diseases. Therefore, targeting oxidative stress and inflammation might contribute to …

Resolvin D5 (RvD5) is a lipid mediator that has been reported to present anti-inflammatory
and pro-resolution properties. Evidence also supports its capability to enhance reactive …