Results: As an outcome the search for a prodrug or mutual prodrug with reduced toxicity has
continued during recent years. This present review emphasizes the common help to revamp …

Modifications of (RS)-2-[4-(2-methylpropyl) phenyl] propanoic acid with amino acid isopropyl
esters were synthesised using different methods via a common intermediate. The main …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs
worldwide and represent a mainstay in the therapy of acute and chronic pain and …

We report a new prodrug micelle-based approach in which a model hydrophobic non-
steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain relief and
inflammation management, but there are challenges related to poor solubility and …

Synthesis of new Schiff base derivatives bearing a 6-nitro-2-ibuprofenyl-4 (3H)-quinazolin-4-
one skeleton, as well as their in vitro biological evaluation as inhibitors of nitric oxide …

The in vitro biological assessment of novel hybrid phospha-oxazepino derivatives bearing
ibuprofenyl quinazolinone moiety as preventing stroke symptoms and inhibitors of nitric …

Prodrugs or predrugs are inactive molecules which become active after in vivo conversion to
release the active parent drug. The prodrug's cleavage can be catalyzed by metabolic …

We reviewed scientific literature on the synthesis of acetaminophen and ibuprofen, as well
as their derivatives and biological properties. The synthesis of acetaminophen involves the …

The two most significant as well as historically important non-steroidal and anti-inflammatory
medications (NSAIDs), aspirin and ibuprofen, are frequently used to treat fever, pain, and …