Emerging evidence points to a strong association between the gut microbiota and the risk,
development and progression of gastrointestinal cancers such as colorectal cancer (CRC) …

The gastrointestinal tract is the site of nutrient digestion and absorption and is also colonized
by diverse, highly mutualistic microbes. The intestinal microbiota has diverse effects on the …

Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a wide
spectrum of liver injuries, ranging from hepatic steatosis, metabolic dysfunction-associated …

The complex metabolic relationships between the host and its microbiota change throughout
life and vary extensively between individuals, affecting disease risk factors and therapeutic …

Increasing evidence indicates that the gut microbiota can be altered to ameliorate or prevent
disease states, and engineering the gut microbiota to therapeutically modulate host …

Evidence suggests that the hyperammonemia (HA)-induced neuroinflammation and
alterations in the serotonin (5-HT) system may contribute to cognitive decline and anxiety …

Hepatic encephalopathy (HE) is a neurological disorder that occurs in patients with liver
insufficiency. However, its pathogenesis has not been fully elucidated. Pharmacotherapy is …

This working group of the International Society of Hepatic Encephalopathy and Nitrogen
Metabolism (ISHEN) was commissioned to summarize and update current efforts in the …

Eukaryotes and prokaryotes have developed mutually beneficial relationships over
millennia of evolutionary adaptation. Bacteria in our gut rely on our diet and the protected …

Ammonia is constantly produced as a metabolic waste from amino acid catabolism in
mammals. Ammonia, the toxic waste metabolite, is resolved in the liver where the urea cycle …