Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases

SA Machado, G Pasquarelli-do-Nascimento… - Nutrition & …, 2022 - Springer
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

New advances in adaptive thermogenesis: UCP1 and beyond

ET Chouchani, L Kazak, BM Spiegelman - Cell metabolism, 2019 - cell.com
Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …

Brown adipose tissue—a translational perspective

AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Intestine farnesoid X receptor agonist and the gut microbiota activate G‐protein bile acid receptor‐1 signaling to improve metabolism

P Pathak, C **e, RG Nichols, JM Ferrell… - …, 2018 - Wiley Online Library
Bile acids activate farnesoid X receptor (FXR) and G protein–coupled bile acid receptor‐1
(aka Takeda G protein–coupled receptor‐5 [TGR5]) to regulate bile acid metabolism and …

Control of brown and beige fat development

W Wang, P Seale - Nature reviews Molecular cell biology, 2016 - nature.com
Brown and beige adipocytes expend chemical energy to produce heat and are therefore
important in regulating body temperature and body weight. Brown adipocytes develop in …

Irisin: a hope in understanding and managing obesity and metabolic syndrome

LI Arhire, L Mihalache, M Covasa - Frontiers in endocrinology, 2019 - frontiersin.org
White adipose tissue (WAT) is an endocrine organ highly integrated in homeostasis and
capable of establishing ways of communicating and influencing multiple metabolic …

Brown and beige fat: physiological roles beyond heat generation

S Kajimura, BM Spiegelman, P Seale - Cell metabolism, 2015 - cell.com
Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …

Retracted: Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR‐133/PRDM16 pathway

H Zhang, L Zhu, M Bai, Y Liu, Y Zhan… - … journal of cancer, 2019 - Wiley Online Library
Cancer‐related cachexia is a metabolic syndrome characterized by a wasting disorder of
adipose and skeletal muscle and is accompanied by body weight loss and systemic …

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

L Sidossis, S Kajimura - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Brown adipose tissue (BAT), a specialized fat that dissipates energy to produce heat, plays
an important role in the regulation of energy balance. Two types of thermogenic adipocytes …

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

T Inagaki, J Sakai, S Kajimura - Nature reviews Molecular cell biology, 2016 - nature.com
White adipocytes store excess energy in the form of triglycerides, whereas brown and beige
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …