Malformations of cortical development are common causes of developmental delay and
epilepsy. Some patients have early, severe neurological impairment, but others have …

Malformations of cortical development (MCD) represent a major cause of developmental
disabilities, severe epilepsy, and reproductive disadvantage. Genes that have been …

The mammalian cerebral cortex is characterized by complex patterns of anatomical and
functional areas that differ markedly between species, but the molecular basis for this …

Channelopathies are disorders caused by abnormal ion channel function in differentiated
excitable tissues. We discovered a unique neurodevelopmental channelopathy resulting …

Polymicrogyria is one of the most common malformations of cortical development and is
associated with a variety of clinical sequelae including epilepsy, intellectual disability, motor …

Lissencephaly–pachygyria-severe band heterotopia are diffuse neuronal migration
disorders (NMDs) causing severe, global neurological impairment. Abnormalities of the …

Malformations of cortical development (MCDs) are an important cause of epilepsy and an
extremely interesting group of disorders from the perspective of brain development and its …

Malformations of cortical development (MCDs) are macroscopic or microscopic
abnormalities of the cerebral cortex that arise as a consequence of an interruption to the …

Grey matter heterotopias, demonstrated by MRI, may present with a broad spectrum of
clinical severity. We have studied 33 patients with periventricular nodular heterotopias …

Objective: To determine the types, relative frequencies, clinical features, and MRI
characteristics of malformations of cortical development (MCD) occurring in a cohort of …