Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–
peptide complexes to control phagosomal infections, help B cells, regulate tissue …

Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …

T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an important
immune checkpoint molecule initially identified as a marker of IFN-γ–producing CD4+ and …

Current success of immunotherapy in cancer has drawn attention to the subsets of TH cells
in the tumor which are critical for activation of anti-tumor response either directly by …

Simple Summary The relationship between the immune system and tumours is currently one
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …

Adoptive cell therapy with T cells reprogrammed to express chimeric antigen receptors (CAR-
T cells) has been highly successful in patients with hematological neoplasms. However, its …

CD4+ T helper cells are key regulators of host health and disease. In the original model,
specialized subsets of T helper cells are generated following activation through lineage …

The balance between Th17 cells and regulatory T cells (Tregs) has emerged as a prominent
factor in regulating autoimmunity and cancer. Th17 cells are vital for host defense against …

Successful tumor eradication by chimeric antigen receptor–expressing (CAR-expressing) T
lymphocytes depends on CAR T cell persistence and effector function. We hypothesized that …

Cancer immunotherapy is an increasingly successful strategy for the treatment of patients
who have advanced or conventional therapy-resistant cancers. T cells are key mediators of …