The role of dissociation in ketamine's antidepressant effects
Ketamine produces immediate antidepressant effects and has inspired research into next-
generation treatments. Ketamine also has short term dissociative effects, in which …
generation treatments. Ketamine also has short term dissociative effects, in which …
Novel glutamatergic modulators for the treatment of mood disorders: current status
The efficacy of standard antidepressants is limited for many patients with mood disorders
such as major depressive disorder (MDD) and bipolar depression, underscoring the urgent …
such as major depressive disorder (MDD) and bipolar depression, underscoring the urgent …
The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders
Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …
derived from scientific evidence and supplemented by expert clinical consensus to formulate …
Re-focusing explainability in medicine
L Arbelaez Ossa, G Starke, G Lorenzini… - Digital …, 2022 - journals.sagepub.com
Using artificial intelligence to improve patient care is a cutting-edge methodology, but its
implementation in clinical routine has been limited due to significant concerns about …
implementation in clinical routine has been limited due to significant concerns about …
ERK/mTOR signaling may underlying the antidepressant actions of rapastinel in mice
M Shen, D Lv, X Liu, C Wang - Translational psychiatry, 2022 - nature.com
Rapastinel as the allosteric modulator of N-methyl-D-aspartate receptor (NMDAR) produces
rapid antidepressant-like effects dependent on brain-derived neurotrophic factor (BDNF) …
rapid antidepressant-like effects dependent on brain-derived neurotrophic factor (BDNF) …
Antidepressant-like Activity of Patchouli Oil var. Tapak Tuan (Pogostemon cablin Benth) via Elevated Dopamine Level: A Study Using Rat Model
Essential oils are gaining popularity for their use in treating depression, including that
extracted from patchouli leaves and stems (Pogostemon cablin). Herein, we used patchouli …
extracted from patchouli leaves and stems (Pogostemon cablin). Herein, we used patchouli …
Effect of ketamine on sleep in treatment-resistant depression: a systematic review
A Kwaśny, A Włodarczyk, D Ogonowski, WJ Cubała - Pharmaceuticals, 2023 - mdpi.com
Background: Depression is a debilitating disease with a high socioeconomic burden.
Regular antidepressants usually require several weeks to ameliorate symptoms; however …
Regular antidepressants usually require several weeks to ameliorate symptoms; however …
The sirtuin 2 inhibitor AK-7 leads to an antidepressant-like effect in mice via upregulation of CREB1, BDNF, and NTRK2 pathways
Depression is one of the most important and serious health problems in develo**
countries which affects millions of people. It is associated with the decrease of the quality of …
countries which affects millions of people. It is associated with the decrease of the quality of …
[HTML][HTML] Treatment response with esketamine nasal spray plus an oral antidepressant in patients with treatment-resistant depression without evidence of early …
I Turkoz, E Daly, J Singh, X Lin… - The Journal of …, 2021 - legacy.psychiatrist.com
Objective: To evaluate response to esketamine nasal spray plus an oral antidepressant
(ESK+ AD) at day 28 in patients with major depressive disorder (DSM-5) and treatment …
(ESK+ AD) at day 28 in patients with major depressive disorder (DSM-5) and treatment …
Participation of the serotonergic system and brain-derived neurotrophic factor in the antidepressant-like effect of flavonoids
Depressive disorders are among the most disabling diseases experienced around the
world, and their incidence has significantly increased over the last few decades due to …
world, and their incidence has significantly increased over the last few decades due to …