Galectin-9 as a biomarker of disease severity
Abstract Galectin-9 (Gal-9) is a β-galactoside binding lectin known for its immunomodulatory
role in various microbial infections. Gal-9 is expressed in all organ systems and localized in …
role in various microbial infections. Gal-9 is expressed in all organ systems and localized in …
Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse
Background Responses to conventional donor lymphocyte infusion for postallogeneic
hematopoietic cell transplantation (HCT) relapse are typically poor. Natural killer (NK) cell …
hematopoietic cell transplantation (HCT) relapse are typically poor. Natural killer (NK) cell …
Immune checkpoint blockade in HIV
Antiretroviral therapy (ART) has dramatically improved life expectancy for people with HIV
(PWH) and helps to restore immune function but is not curative and must be taken lifelong …
(PWH) and helps to restore immune function but is not curative and must be taken lifelong …
Galectin-9, a player in cytokine release syndrome and a surrogate diagnostic biomarker in SARS-CoV-2 infection
N Bozorgmehr, S Mashhouri, E Perez Rosero, L Xu… - MBio, 2021 - Am Soc Microbiol
The outbreak of SARS-CoV-2 infection has enormously impacted our lives. Clinical
evidence has implicated the emergence of cytokine release syndrome as the prominent …
evidence has implicated the emergence of cytokine release syndrome as the prominent …
The quality of SARS-CoV-2–specific T cell functions differs in patients with mild/moderate versus severe disease, and T cells expressing coinhibitory receptors are …
Understanding the function of SARS-CoV-2 Ag-specific T cells is crucial for the monitoring of
antiviral immunity and vaccine design. Currently, both impaired and robust T cell immunity is …
antiviral immunity and vaccine design. Currently, both impaired and robust T cell immunity is …
Analysis of SARS-CoV-2 isolates, namely the Wuhan strain, Delta variant, and Omicron variant, identifies differential immune profiles
There is an urgent need to better understand the impact of different severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants on immune response and disease …
syndrome coronavirus 2 (SARS-CoV-2) variants on immune response and disease …
Galectin-9 promotes natural killer cells activity via interaction with CD44
Natural killer (NK) cells are a potent innate source of cytokines and cytoplasmic granules.
Their effector functions are tightly synchronized by the balance between the stimulatory and …
Their effector functions are tightly synchronized by the balance between the stimulatory and …
[HTML][HTML] Galectin-9 expression defines exhausted T cells and impaired cytotoxic NK cells in patients with virus-associated solid tumors
I Okoye, L Xu, M Motamedi, P Parashar… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background We have previously reported that the upregulation of galectin-9 (Gal-9) on
CD4+ and CD8+ T cells in HIV patients was associated with impaired T cell effector …
CD4+ and CD8+ T cells in HIV patients was associated with impaired T cell effector …
Tumor-derived exosomes induced M2 macrophage polarization and promoted the metastasis of osteosarcoma cells through Tim-3
Z Cheng, L Wang, C Wu, L Huang, Y Ruan… - Archives of medical …, 2021 - Elsevier
Introduction Osteosarcoma, the most prevalent primary malignancy of the bone, is often
presented with high-grade subclinical metastatic disease that metastasizes at very early …
presented with high-grade subclinical metastatic disease that metastasizes at very early …
Galectin-9 and VISTA expression define terminally exhausted T cells in HIV-1 infection
We report significant upregulation of Galectin-9 (Gal-9) and VISTA on both CD4+ and CD8+
T cells in HIV-infected human patients. Gal-9 and VISTA expression was associated with …
T cells in HIV-infected human patients. Gal-9 and VISTA expression was associated with …