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Comprehensive overview of the structure and regulation of the glucocorticoid receptor
S Vandevyver, L Dejager, C Libert - Endocrine reviews, 2014 - academic.oup.com
Glucocorticoids are among the most prescribed drugs worldwide for the treatment of
numerous immune and inflammatory disorders. They exert their actions by binding to the …
numerous immune and inflammatory disorders. They exert their actions by binding to the …
Pharmacogenomic response of inhaled corticosteroids for the treatment of asthma: considerations for therapy
There is a large interindividual variability in response to ICSs in asthma. About 70% of the
variance in ICS response is likely due at least partially to genetically determined …
variance in ICS response is likely due at least partially to genetically determined …
Genetic associations of the response to inhaled corticosteroids in children during an asthma exacerbation
Background Genetic associations of the response to inhaled corticosteroids (ICS s) during
an asthma exacerbation are unknown. Objective To evaluate the role of genetic variants in …
an asthma exacerbation are unknown. Objective To evaluate the role of genetic variants in …
Cytokine TGFβ gene polymorphism in asthma: TGF-related SNP analysis enhances the prediction of disease diagnosis (a case-control study with multivariable data …
Introduction TGF-β and its receptors play a crucial role in asthma pathogenesis and
bronchial remodeling in the course of the disease. TGF-β1, TGF-β2, and TGF-β3 isoforms …
bronchial remodeling in the course of the disease. TGF-β1, TGF-β2, and TGF-β3 isoforms …
SFTPB (rs11130866) and NR3C1 (rs41423247) gene variants as potential clinical biomarkers for personalized treatment strategy selection in patients with severe …
Background Exploring the pathogenetic mechanisms behind severe lung damage in COVID-
19 is crucial. In this study, we decided to focus on two molecular markers that affect …
19 is crucial. In this study, we decided to focus on two molecular markers that affect …
[HTML][HTML] Association analysis of the glucocorticoid receptor gene (NR3C1) haplotypes (ER22/23EK, N363S, BclI) with mood and anxiety disorders in patients with …
Chronic inflammation in the bronchi of long-term asthma patients worsens mood disorders,
which has been shown to correlate with elevated levels of multiple proinflammatory …
which has been shown to correlate with elevated levels of multiple proinflammatory …
The NR3C1 glucocorticoid receptor gene polymorphisms may modulate the TGF-beta mRNA expression in asthma patients
Glucocorticosteroids (GCs) are basic drugs in therapy of a number of diseases, including
chronic diseases of the respiratory system. They are the most important anti-inflammatory …
chronic diseases of the respiratory system. They are the most important anti-inflammatory …
Influence of glucocorticoid receptor gene NR3C1 646 C> G polymorphism on glucocorticoid resistance in asthmatics: a preliminary study
Background: Glucocorticoid receptor gene polymorphism (NR3C1 646 C> G) may play an
important role in the development of severe bronchial asthma and resistance to …
important role in the development of severe bronchial asthma and resistance to …
Dual biomarkers long non-coding RNA GAS5 and its target, NR3C1, contribute to acute myeloid leukemia
Acute myeloid leukemia (AML) is a complex hematological neoplasm with poor prognosis.
At present, overwhelming evidence indicates that different genetic abnormalities are …
At present, overwhelming evidence indicates that different genetic abnormalities are …
A novel approach to understanding the role of polymorphic forms of the NR3C1 and TGF-β1 genes in the modulation of the expression of IL-5 and IL-15 mRNA in …
M Panek, M Jonakowski, J Zioło… - Molecular …, 2016 - spandidos-publications.com
The aim of the present study was to identify polymorphic forms of the nuclear receptor
subfamily 3, group C, member 1 (NR3C1) and transforming growth factor β1 (TGF-β1) genes …
subfamily 3, group C, member 1 (NR3C1) and transforming growth factor β1 (TGF-β1) genes …