The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-
activated protein kinase (AMPK), which is activated when intracellular ATP production …
activated protein kinase (AMPK), which is activated when intracellular ATP production …
AMPK: an energy-sensing pathway with multiple inputs and outputs
AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …
Cortical evolution: judge the brain by its cover
To understand the emergence of human higher cognition, we must understand its biological
substrate—the cerebral cortex, which considers itself the crowning achievement of evolution …
substrate—the cerebral cortex, which considers itself the crowning achievement of evolution …
[HTML][HTML] AMPK: potential therapeutic target for ischemic stroke
S Jiang, T Li, T Ji, W Yi, Z Yang, S Wang, Y Yang… - Theranostics, 2018 - ncbi.nlm.nih.gov
AMP-activated protein kinase (AMPK), a member of the serine/threonine (Ser/Thr) kinase
group, is universally distributed in various cells and organs. It is a significant endogenous …
group, is universally distributed in various cells and organs. It is a significant endogenous …
Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis
H Endo, M Niioka, N Kobayashi, M Tanaka… - PloS one, 2013 - journals.plos.org
Nonalcoholic fatty liver disease (NAFLD) includes simple steatosis, nonalcoholic
steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. The gut-derived …
steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. The gut-derived …
[HTML][HTML] Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture
The molecular mechanisms underlying the axon arborization of mammalian neurons are
poorly understood but are critical for the establishment of functional neural circuits. We …
poorly understood but are critical for the establishment of functional neural circuits. We …
AMPK in the brain: its roles in glucose and neural metabolism
The adenosine monophosphate‐activated protein kinase (AMPK) is an integrative metabolic
sensor that maintains energy balance at the cellular level and plays an important role in …
sensor that maintains energy balance at the cellular level and plays an important role in …
The interplay of axonal energy homeostasis and mitochondrial trafficking and anchoring
ZH Sheng - Trends in cell biology, 2017 - cell.com
Mitochondria are key cellular power plants essential for neuronal growth, survival, function,
and regeneration after injury. Given their unique morphological features, neurons face …
and regeneration after injury. Given their unique morphological features, neurons face …
mTOR: A pathogenic signaling pathway in developmental brain malformations
PB Crino - Trends in molecular medicine, 2011 - cell.com
The mTOR signaling network functions as a pivotal regulatory cascade during the
development of the cerebral cortex. Aberrant hyperactivation of mTOR as a consequence of …
development of the cerebral cortex. Aberrant hyperactivation of mTOR as a consequence of …
Identification of AMPK phosphorylation sites reveals a network of proteins involved in cell invasion and facilitates large-scale substrate prediction
BE Schaffer, RS Levin, NT Hertz, TJ Maures… - Cell metabolism, 2015 - cell.com
AMP-activated protein kinase (AMPK) is a central energy gauge that regulates metabolism
and has been increasingly involved in non-metabolic processes and diseases. However …
and has been increasingly involved in non-metabolic processes and diseases. However …