Inflammation, stress and depression: an exploration of ketamine's therapeutic profile

JN Johnston, MS Greenwald, ID Henter, C Kraus… - Drug discovery today, 2023 - Elsevier
Highlights•Chronic stress, depression and inflammation have been consistently
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …

[HTML][HTML] Biomarkers of post-COVID depression

P Lorkiewicz, N Waszkiewicz - Journal of Clinical medicine, 2021 - mdpi.com
The COVID-19 pandemic is spreading around the world and 187 million people have
already been affected. One of its after-effects is post-COVID depression, which, according to …

Using network analysis to examine links between individual depressive symptoms, inflammatory markers, and covariates

EI Fried, S Von Stockert, JMB Haslbeck… - Psychological …, 2020 - cambridge.org
BackgroundStudies investigating the link between depressive symptoms and inflammation
have yielded inconsistent results, which may be due to two factors. First, studies differed …

Association between systemic inflammation and individual symptoms of depression: a pooled analysis of 15 population-based cohort studies

P Frank, M Jokela, GD Batty, D Cadar… - American Journal of …, 2021 - psychiatryonline.org
Objective: Evidence from anti-inflammatory drug trials for the treatment of depression has
been inconsistent. This may be ascribed to the differing symptom-specific effects of …

Longitudinal association between depression and inflammatory markers: results from the Netherlands study of depression and anxiety

F Lamers, Y Milaneschi, JH Smit, RA Schoevers… - Biological …, 2019 - Elsevier
Background While cross-sectional associations of inflammatory markers interleukin-6 (IL-6)
and C-reactive protein with major depressive disorder are well established, evidence for …

[HTML][HTML] C-reactive protein as a biomarker for major depressive disorder?

L Orsolini, S Pompili, S Tempia Valenta, V Salvi… - International journal of …, 2022 - mdpi.com
The etiopathogenesis of depression is not entirely understood. Several studies have
investigated the role of inflammation in major depressive disorder. The present work aims to …

[HTML][HTML] Depression profilers and immuno-metabolic dysregulation: Longitudinal results from the NESDA study

F Lamers, Y Milaneschi, CH Vinkers… - Brain, Behavior, and …, 2020 - Elsevier
Background Major depressive disorder (MDD) is linked to higher cardio-metabolic
comorbidity that may in part be due to the low-grade inflammation and poorer metabolic …

Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression

J Lasselin, M Lekander, S Benson, M Schedlowski… - Molecular …, 2021 - nature.com
Depression is one of the global leading causes of disability, but treatments remain limited
and classical antidepressants were found to be ineffective in a substantial proportion of …

Depression: Biological markers and treatment

GN Erjavec, M Sagud, MN Perkovic, DS Strac… - Progress in Neuro …, 2021 - Elsevier
Nowadays depression is considered as a systemic illness with different biological
mechanisms involved in its etiology, including inflammatory response, hypothalamic …

Changes in inflammatory biomarkers are related to the antidepressant effects of Ayahuasca

NL Galvão-Coelho… - Journal of …, 2020 - journals.sagepub.com
Background: Ayahuasca is a traditional Amazon brew and its potential antidepressant
properties have recently been explored in scientific settings. We conducted a double-blind …