Although classically appreciated for their role as the powerhouse of the cell, the metabolic
functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …

The uptake and metabolism of nutrients support fundamental cellular process from
bioenergetics to biomass production and cell fate regulation. While many studies of cell …

Cancer cells rewire their metabolism and rely on endogenous antioxidants to mitigate lethal
oxidative damage to lipids. However, the metabolic processes that modulate the response to …

Ferroptosis, a form of regulated cell death that is driven by iron-dependent phospholipid
peroxidation, has been implicated in multiple diseases, including cancer,–, degenerative …

Lactate is abundant in rapidly dividing cells owing to the requirement for elevated glucose
catabolism to support proliferation,,,,–. However, it is not known whether accumulated lactate …

Great strides have been made over the past decade toward comprehensive study of
metabolism. Mass spectrometry (MS) has played a central role by enabling measurement of …

Advancements in precision oncology over the past decades have led to new therapeutic
interventions, but the efficacy of such treatments is generally limited by an adaptive process …

The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key
roles in oxidative metabolism. Mitochondria, as the major site of oxidative reactions, must …

The lysosome degrades and recycles macromolecules, signals to the cytosol and nucleus,
and is implicated in many diseases. Here, we describe a method for the rapid isolation of …