Almost all human diseases are strongly associated with inflammation, and a deep
understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome …

Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

Inflammasomes are multiprotein complexes that activate caspase-1, which leads to
maturation of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 and the …

Innate immune responses have the ability to both combat infectious microbes and drive
pathological inflammation. Inflammasome complexes are a central component of these …

Altered metabolism has been implicated in the pathogenesis of inflammatory diseases.
NADPH oxidase 4 (NOX4), a source of cellular superoxide anions, has multiple biological …

Meningitis is an inflammation of the meninges and subarachnoid space that can also involve
the brain cortex and parenchyma. It can be acquired spontaneously in the community …

Coronaviruses (CoVs) are members of the genus Betacoronavirus and the Coronaviridiae
family responsible for infections such as severe acute respiratory syndrome (SARS), Middle …

Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …

Inflammasomes are cytosolic multiprotein complexes that assemble in response to a variety
of infectious and noxious insults. Inflammasomes play a critical role in the initiation of innate …

Inhibiting the NLRP3 inflammasome mediates inflammation in an extensive number of
preclinical models. As excitement in this field has grown, several companies have recently …