Since its discovery over 350 years ago, studies of fibrinogen have revealed remarkable
characteristics. Its complex structure as a large (340 kD a) hexameric homodimer supports …

Interfacial polymerization is an enabling technique for the large-scale production of ultrathin
layers, hollow nanospheres and nanofibers. The availability of a wide range of suitable …

How soft corona, the protein corona's outer layer, contributes to biological identity of
nanomaterials is largely because capturing protein composition of the soft corona in situ …

Many nanoscale biomaterials fail to reach the clinical trial stage due to a poor understanding
of the fundamental principles of their in vivo behaviour. Here we describe the transport …

Here we have investigated the effect of enshrouding polymer-coated nanoparticles (NPs)
with polyethylene glycol (PEG) on the adsorption of proteins and uptake by cultured cells …

Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …

The interaction of coagulation factors with the perivascular environment affects the
development of disease in ways that extend beyond their traditional roles in the acute …

Wound healing is a complex process and rapid healing necessitates a proper micro-
environment. Therefore, design and fabrication of an efficacious wound dressing is an …

Protein solubility is a problem for many protein chemists, including structural biologists and
developers of protein pharmaceuticals. Knowledge about how intrinsic factors influence …

Natural polymers such as collagens, elastin, and fibrinogen make up much of the body's
native extracellular matrix (ECM). This ECM provides structure and mechanical integrity to …