Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020

P Everts, K Onishi, P Jayaram, JF Lana… - International journal of …, 2020 - mdpi.com
Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications
have the potential to play adjunctive roles in a variety of regenerative medicine treatment …

NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

Programmed cell death detection methods: a systematic review and a categorical comparison

S Kari, K Subramanian, IA Altomonte, A Murugesan… - Apoptosis, 2022 - Springer
Programmed cell death is considered a key player in a variety of cellular processes that
helps to regulate tissue growth, embryogenesis, cell turnover, immune response, and other …

Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics

Y Lee, M Jeong, J Park, H Jung, H Lee - Experimental & Molecular …, 2023 - nature.com
Several studies have utilized a lipid nanoparticle delivery system to enhance the
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …

[HTML][HTML] Cell death

K Newton, A Strasser, N Kayagaki, VM Dixit - Cell, 2024 - cell.com
Cell death supports morphogenesis during development and homeostasis after birth by
removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating …

Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment

L Wang, Y Liu, Y Dai, X Tang, T Yin, C Wang, T Wang… - Gut, 2023 - gut.bmj.com
Objective Innate immunity plays important roles in pancreatic ductal adenocarcinoma
(PDAC), as non-T-cell-enriched tumour. Neutrophils are major players in innate immune …

Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment

Y Wu, S Wan, S Yang, H Hu, C Zhang, J Lai… - Journal of …, 2022 - Springer
Synthetic nanoparticles with surface bioconjugation are promising platforms for targeted
therapy, but their simple biological functionalization is still a challenging task against the …

Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets

L Vande Walle, M Lamkanfi - Nature Reviews Drug Discovery, 2024 - nature.com
Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …

Ketamine and ketamine metabolite pharmacology: insights into therapeutic mechanisms

P Zanos, R Moaddel, PJ Morris, LM Riggs… - Pharmacological …, 2018 - Elsevier
Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

Myeloid-derived suppressor cells coming of age

F Veglia, M Perego, D Gabrilovich - Nature immunology, 2018 - nature.com
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells
generated during a large array of pathologic conditions ranging from cancer to obesity …