Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a type of glycosylation that
occurs when a monosaccharide, O-GlcNAc, is added onto serine or threonine residues of …

The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …

A variety of tissue lineages can be differentiated from pluripotent stem cells by mimicking
embryonic development through stepwise exposure to morphogens, or by conversion of one …

The role of the microenvironment in T cell acute lymphoblastic leukemia (T-ALL), or any
acute leukemia, is poorly understood. Here we demonstrate that T-ALL cells are in direct …

WNT proteins are secreted morphogens that are required for basic developmental
processes, such as cell-fate specification, progenitor-cell proliferation and the control of …

T cell receptor (TCR) β-selection (herein referred to as β-selection) is a pivotal checkpoint in
mammalian T cell development when immature CD4–CD8–T-cells (thymocytes) express pre …

T cells develop in the thymus and are critical for adaptive immunity. Natural killer (NK)
lymphocytes constitute an essential component of the innate immune system in tumor …

Double‐negative (DN) T cells are present at relatively low frequencies in human peripheral
blood, and are characterized as expressing the alpha‐beta or gamma‐delta T‐cell receptor …

Transcription factors play important roles in lymphopoiesis. We have previously
demonstrated that Bcl11a is essential for normal lymphocyte development in the mouse …

Recent studies have shown that T cells are not just the latecomers in inflammation but might
also play a key role in the early phase of this response. In this context, a number of T cell …