A catalogue of signal molecules that interact with sensor kinases, chemoreceptors and transcriptional regulators
MA Matilla, F Velando, D Martín-Mora… - FEMS Microbiology …, 2022 - academic.oup.com
Bacteria have evolved many different signal transduction systems that sense signals and
generate a variety of responses. Generally, most abundant are transcriptional regulators …
generate a variety of responses. Generally, most abundant are transcriptional regulators …
Mechanisms of bacterial tolerance and persistence in the gastrointestinal and respiratory environments
R Trastoy, T Manso, L Fernández-García… - Clinical microbiology …, 2018 - Am Soc Microbiol
Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense
pressure due to the environmental conditions of the surroundings. This pressure has led to …
pressure due to the environmental conditions of the surroundings. This pressure has led to …
Staphylococcal response to oxidative stress
R Gaupp, N Ledala, GA Somerville - Frontiers in cellular and infection …, 2012 - frontiersin.org
Staphylococci are a versatile genus of bacteria that are capable of causing acute and
chronic infections in diverse host species. The success of staphylococci as pathogens is due …
chronic infections in diverse host species. The success of staphylococci as pathogens is due …
Bacterial single-cell RNA sequencing captures biofilm transcriptional heterogeneity and differential responses to immune pressure
Biofilm formation is an important mechanism of survival and persistence for many bacterial
pathogens. These multicellular communities contain subpopulations of cells that display …
pathogens. These multicellular communities contain subpopulations of cells that display …
Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus
Hydrogen sulfide (H2S) is thought to protect bacteria from oxidative stress, but a
comprehensive understanding of its function in bacteria is largely unexplored. In this study …
comprehensive understanding of its function in bacteria is largely unexplored. In this study …
The CsoR‐like sulfurtransferase repressor (CstR) is a persulfide sensor in Staphylococcus aureus
JL Luebke, J Shen, KE Bruce, TE Kehl‐Fie… - Molecular …, 2014 - Wiley Online Library
How cells regulate the bioavailability of utilizable sulfur while mitigating the effects of
hydrogen sulfide toxicity is poorly understood. CstR [C opper‐sensing operon repressor (C …
hydrogen sulfide toxicity is poorly understood. CstR [C opper‐sensing operon repressor (C …
Thiol-based redox switches in the major pathogen Staphylococcus aureus
N Linzner, VV Loi, VN Fritsch, H Antelmann - Biological Chemistry, 2021 - degruyter.com
Staphylococcus aureus is a major human pathogen, which encounters reactive oxygen,
nitrogen, chlorine, electrophile and sulfur species (ROS, RNS, RCS, RES and RSS) by the …
nitrogen, chlorine, electrophile and sulfur species (ROS, RNS, RCS, RES and RSS) by the …
Control of Clostridium difficile physiopathology in response to cysteine availability
The pathogenicity of Clostridium difficile is linked to its ability to produce two toxins: TcdA
and TcdB. The level of toxin synthesis is influenced by environmental signals, such as …
and TcdB. The level of toxin synthesis is influenced by environmental signals, such as …
Virulence factors produced by Staphylococcus aureus biofilms have a moonlighting function contributing to biofilm integrity*[S]
AC Graf, A Leonard, M Schäuble… - Molecular & Cellular …, 2019 - ASBMB
Staphylococcus aureus is the causative agent of various biofilm-associated infections in
humans causing major healthcare problems worldwide. This type of infection is inherently …
humans causing major healthcare problems worldwide. This type of infection is inherently …
Sulfide homeostasis and nitroxyl intersect via formation of reactive sulfur species in Staphylococcus aureus
Staphylococcus aureus is a commensal human pathogen and a major cause of nosocomial
infections. As gaseous signaling molecules, endogenous hydrogen sulfide (H2S) and nitric …
infections. As gaseous signaling molecules, endogenous hydrogen sulfide (H2S) and nitric …