A catalogue of signal molecules that interact with sensor kinases, chemoreceptors and transcriptional regulators

MA Matilla, F Velando, D Martín-Mora… - FEMS Microbiology …, 2022 - academic.oup.com
Bacteria have evolved many different signal transduction systems that sense signals and
generate a variety of responses. Generally, most abundant are transcriptional regulators …

Mechanisms of bacterial tolerance and persistence in the gastrointestinal and respiratory environments

R Trastoy, T Manso, L Fernández-García… - Clinical microbiology …, 2018 - Am Soc Microbiol
Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense
pressure due to the environmental conditions of the surroundings. This pressure has led to …

Staphylococcal response to oxidative stress

R Gaupp, N Ledala, GA Somerville - Frontiers in cellular and infection …, 2012 - frontiersin.org
Staphylococci are a versatile genus of bacteria that are capable of causing acute and
chronic infections in diverse host species. The success of staphylococci as pathogens is due …

Bacterial single-cell RNA sequencing captures biofilm transcriptional heterogeneity and differential responses to immune pressure

LE Korshoj, T Kielian - Nature Communications, 2024 - nature.com
Biofilm formation is an important mechanism of survival and persistence for many bacterial
pathogens. These multicellular communities contain subpopulations of cells that display …

Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus

H Peng, Y Zhang, LD Palmer, TE Kehl-Fie… - ACS infectious …, 2017 - ACS Publications
Hydrogen sulfide (H2S) is thought to protect bacteria from oxidative stress, but a
comprehensive understanding of its function in bacteria is largely unexplored. In this study …

The CsoR‐like sulfurtransferase repressor (CstR) is a persulfide sensor in Staphylococcus aureus

JL Luebke, J Shen, KE Bruce, TE Kehl‐Fie… - Molecular …, 2014 - Wiley Online Library
How cells regulate the bioavailability of utilizable sulfur while mitigating the effects of
hydrogen sulfide toxicity is poorly understood. CstR [C opper‐sensing operon repressor (C …

Thiol-based redox switches in the major pathogen Staphylococcus aureus

N Linzner, VV Loi, VN Fritsch, H Antelmann - Biological Chemistry, 2021 - degruyter.com
Staphylococcus aureus is a major human pathogen, which encounters reactive oxygen,
nitrogen, chlorine, electrophile and sulfur species (ROS, RNS, RCS, RES and RSS) by the …

Control of Clostridium difficile physiopathology in response to cysteine availability

T Dubois, M Dancer-Thibonnier, M Monot… - Infection and …, 2016 - Am Soc Microbiol
The pathogenicity of Clostridium difficile is linked to its ability to produce two toxins: TcdA
and TcdB. The level of toxin synthesis is influenced by environmental signals, such as …

Virulence factors produced by Staphylococcus aureus biofilms have a moonlighting function contributing to biofilm integrity*[S]

AC Graf, A Leonard, M Schäuble… - Molecular & Cellular …, 2019 - ASBMB
Staphylococcus aureus is the causative agent of various biofilm-associated infections in
humans causing major healthcare problems worldwide. This type of infection is inherently …

Sulfide homeostasis and nitroxyl intersect via formation of reactive sulfur species in Staphylococcus aureus

H Peng, J Shen, KA Edmonds, JL Luebke, AK Hickey… - MSphere, 2017 - Am Soc Microbiol
Staphylococcus aureus is a commensal human pathogen and a major cause of nosocomial
infections. As gaseous signaling molecules, endogenous hydrogen sulfide (H2S) and nitric …