Importance Several studies have reported antidepressant effects of anti-inflammatory
treatment; however, the results have been conflicting and detrimental adverse effects may …

Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

Depression and anxiety are the most prevalent neuropsychiatric disorders that have
emerged as global health concerns. Anxiolytic and antidepressant drugs, such as …

Psychiatric disorders associated with psychological trauma, stress and anxiety are a highly
prevalent and increasing cause of morbidity worldwide. Current therapeutic approaches …

Background Determining etiological factors and reviewing advances in diagnostic
modalities sensitive and specific to Major Depressive Disorder (MDD) is of importance in its …

Major depression is a prevalent illness that increases the risk of several neurological
conditions. These include stroke, cardiovascular disease, and dementia including …

Depression stands as a prominent contributor to global disability, entailing an elevated risk
of suicide. Substantial evidence supports the notion that immune dysregulation may play a …

Major depressive disorder (MDD) is characterized by mood, vegetative, cognitive, and even
psychotic symptoms and signs that can cause substantial impairments in quality of life and …

Regulation of emotions is generally associated exclusively with the brain. However, there is
evidence that peripheral systems are also involved in mood, stress vulnerability vs …

Millions of people around the world suffer from psychiatric illnesses, causing unbearable
burden and immense distress to patients and their families. Accumulating evidence …