Almost half the cells and 1% of the unique genes found in our bodies are human, the rest
are from microbes, predominantly bacteria, archaea, fungi, and viruses. These …

A comprehensive understanding of host–pathogen interactions requires a knowledge of the
associated gene expression changes in both the pathogen and the host. Traditional, probe …

Strand-specific, massively parallel cDNA sequencing (RNA-seq) is a powerful tool for
transcript discovery, genome annotation and expression profiling. There are multiple …

The human body is constantly exposed to microorganisms, which entails manifold
interactions between human cells and diverse commensal or pathogenic bacteria. The …

Understanding the control of gene expression is critical for our understanding of the
relationship between genotype and phenotype. The need for reliable assessment of …

Genome-wide studies of bacterial gene expression are shifting from microarray technology
to second generation sequencing platforms. RNA-seq has a number of advantages over …

Candida albicans is an opportunistic human fungal pathogen that causes candidiasis. As
healthcare has been improved worldwide, the number of immunocompromised patients has …

Enterococcus faecalis is a Gram-positive commensal member of the gut microbiota of a wide
range of organisms. With the advent of antibiotic therapy, it has emerged as a multidrug …

RNA sequencing provides a new perspective on the genome of Mycobacterium tuberculosis
by revealing an extensive presence of non-coding RNA, including long 5'and 3'untranslated …

Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of
multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be …