Macrophages play a central role in the development of atherosclerotic cardiovascular
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …

Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

Tissue-resident and recruited macrophages contribute to both host defense and pathology.
Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep …

The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the
clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a …

Tissue environment plays a powerful role in establishing and maintaining the distinct
phenotypes of resident macrophages, but the underlying molecular mechanisms remain …

All mammalian cell membranes contain cholesterol to maintain membrane integrity. The
transport of this hydrophobic lipid is mediated by lipoproteins. Cholesterol is especially …

Enhanced de novo lipogenesis mediated by sterol regulatory element–binding proteins
(SREBPs) is thought to be involved in nonalcoholic steatohepatitis (NASH) pathogenesis. In …

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and
a major cause of liver cirrhosis and hepatocellular carcinoma. NAFLD is intimately linked …

Cardiovascular disease (CVD) accounts for almost half of all deaths related to non-
communicable disease worldwide, making it the single largest global cause of mortality …

Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory
and proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown …